Balancing Hormones with the Endocannabinoid System: How Cannabinoids Can Support Hormonal Signaling
By Guest Bloggers Elisabeth & Sherri Mack
Hormonal imbalance is one of the most under-recognized drivers of modern chronic disease. Whether you're experiencing stress, sleeplessness, reproductive challenges, or metabolic conditions like obesity or diabetes, your hormones are likely involved. But what if the key to restoring balance lay not in your hormone glands themselves, but in the system that regulates them? That system is the endocannabinoid system (ECS), a master homeostatic regulator that influences nearly every endocrine axis in the body.
The Endocannabinoid System (ECS) plays a regulatory role in hormonal signaling across multiple endocrine axes. It acts as a homeostatic regulator, influencing how hormones are released, how feedback loops operate, and how the body responds to both internal and external stressors.
Let’s take a closer look at how the ECS and Bloom Hemp’s targeted CBD products may support hormonal balance, and meet a few patients along the way who found relief through cannabis therapeutics.
What Is the Endocannabinoid System (ECS) and How Does It Affect Hormones?
The ECS is composed of:
Endocannabinoids like anandamide (AEA) and 2-AG that we make internally upon demand to correct cell signaling for systemic homeostasis.
Cannabinoid receptors (CB1 and CB2) are located on the cell surfaces of all 11 organ systems, as well as within the immune system and at key junctions of neurotransmitter signaling pathways.
Enzymes such as FAAH and MAGL are responsible for synthesizing and breaking down endocannabinoids after they have been utilized by the body.
These elements are present in the hypothalamus, pituitary, adrenal glands, thyroid, pancreas, ovaries, and testes, which means the ECS has the potential to modulate hormonal activity at every level (Hill & Tasker, 2012).
Stress and the HPA Axis: Regulating Cortisol with Cannabinoids - The Endocannabinoid System (ECS) modulates the hypothalamic-pituitary-adrenal (HPA) axis, which governs cortisol release. CB1 receptor activation in the brain can suppress HPA activity, helping to dampen the stress response. When cannabinoids activate the CB1 receptor, they can reduce the overproduction of cortisol, our primary stress hormone. (Hill & Tasker, 2012).
Patient Spotlight: Maria, a 48-year-old teacher navigating menopause, faced challenges with chronic stress, insomnia, and anxiety. Seeking relief, she turned to Bloom Hemp Products. She began using the Calming Tincture (a blend of CBD, CBN, lavender, hops, california poppy and lemon balm), starting with half a dropper after dinner and before bed, as well as Bloom Hemp’s Full Spectrum Softgels (25mg CBD with 1mg THC) after dinner. Within just two weeks, Maria experienced deeper, more restful sleep and a noticeable reduction in nighttime hot flashes.
Reproductive Hormones and Fertility Support - The endocannabinoid system (ECS) plays a critical role in regulating the release of gonadotropin-releasing hormone (GnRH), which in turn influences key hormones such as luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen, progesterone, and testosterone. Anandamide, an endocannabinoid, fluctuates throughout the menstrual cycle, impacting both ovulation and implantation. Estrogen and progesterone, in turn, modulate the tone of the ECS, creating a dynamic interplay. In women, anandamide levels vary across the menstrual cycle, reflecting these hormonal shifts (Lemoine, 2020). In men, the endocannabinoid system (ECS) plays a crucial role in reproductive health by influencing testosterone production and sperm viability. As highlighted by Milanian et al. (2025), endogenous cannabinoids are key regulators of reproductive hormones, spermatogenesis, sperm motility, maturation, and overall function. This underscores the central importance of the ECS in maintaining male fertility.
Patient Spotlight: Jamie, a 35-year-old managing PCOS, had been trying to conceive with her partner while navigating challenges like insulin resistance and androgen excess. Seeking to improve her gut health and hormonal balance, she turned to Bloom Hemp’s Digestive Tincture—a thoughtful blend of CBD, CBG, coriander, cumin, fennel, and trace amounts of THC. Additionally, she incorporated Bloom Hemp Immunity Softgels, which combine CBD, CBG, CBDA, and CBGA, into her daily routine, taking them twice a day. This powerful combination helped improve her digestion, ease bloating, and regulate her cycle, while also enhancing key metabolic markers.
Thyroid Function: Emerging Research and ECS Modulation - CB1 receptors are also present in the thyroid gland, an important organ responsible for regulating metabolism, energy levels, and overall hormonal balance within the body. While human studies exploring the relationship between CB1 receptors and thyroid function remain limited, preclinical research has provided some insights. Findings suggest that modulation of the endocannabinoid system (ECS) may influence the secretion of thyroid-stimulating hormone (TSH) and subsequently affect downstream thyroid hormones, which play a critical role in numerous physiological processes. This early research opens the door for further investigation into how ECS activity may impact thyroid health and overall endocrine function. (Cannakeys)
Patient Spotlight: Erica, 42, who lives with Hashimoto’s thyroiditis, integrated Bloom Hemp's Full Spectrum Recovery Tincture (a blend of CBD, CBG, turmeric, ginger, black cumin, and trace amounts of THC), Immunity Softgels (featuring CBD, CBG, CBDA, and CBGA), and the Bloom Hemp Muscle and Joint Cream into her daily routine to manage persistent joint pain and muscle aches. Since making these changes, she has experienced significant benefits, including reduced joint discomfort, increased energy, and better support during flare-ups.
Metabolic Health, Obesity & Diabetes - The Endocannabinoid System (ECS) plays a key role in regulating metabolism, appetite, and energy homeostasis, which are crucial factors in the development of obesity and type 2 diabetes. Overactivation of the ECS—particularly CB1 receptor signaling in peripheral tissues—is linked to increased appetite, insulin resistance, leptin resistance, and fat accumulation (Di Marzo, 2008). Leptin, a hormone involved in satiety, can downregulate ECS activity, forming a feedback loop that influences energy balance. Preclinical studies suggest that CBD may support metabolic health by promoting the browning of white adipose tissue and reducing inflammation, while CB1 antagonists such as tetrahydrocannabivarin (THCV) have shown potential to decrease insulin resistance and improve glucose tolerance (Silvestri et al., 2015; Wargent et al., 2013).
In May 2024, Bloom Hemp partnered with the MoreBetter Releaf App to study the effects of the Bloom Hemp Advanced Focus Tincture. Participants tracked their focus, concentration, and energy for 7 days without the tincture, followed by 21 days of using it. The Bloom Hemp Advanced Focus Tincture study revealed significant improvements in energy, focus, stress management, and overall mood. Participants also reported an impressive productivity boost, gaining over two additional hours of efficiency each day. Notably, the tincture demonstrated measurable effects on appetite and weight management. Over half of the participants (51.9%) experienced reduced appetite throughout the day, and 24.1% reported weight loss while using Bloom Hemp’s Advanced Focus Tincture (Bloom Hemp)
Bloom Hemp Advanced Focus Tincture is a 6:1:1 CBD (1200), CBG (200), THCV (200) blend. It is non-impairing, USDA Organic, full spectrum, and our #1 Selling product for balanced energy, improved cognition, reduced appetite, and enhanced metabolic function. Bloom Hemp is excited to share the results of our FOCUS study, aimed at helping Americans boost energy and productivity for a more balanced and fulfilling daily life. Read the full report here.
Hormonal Feedback Loops and ECS Crosstalk - The Endocannabinoid System (ECS) does not function in isolation; rather, it interacts dynamically with the hormonal system. It is both modulated by and modulates hormonal fluctuations through feedback loops. For instance, higher levels of estrogen have been shown to suppress the enzyme FAAH, which breaks down anandamide (AEA), thereby increasing circulating AEA levels—particularly at ovulation when estrogen peaks. This rise in anandamide enhances ECS tone and may contribute to why many women report increased sensitivity to cannabis during that phase of the menstrual cycle (Hillard, 2019; Russo, 2016). This illustrates the nuanced and reciprocal relationship between the ECS and estrogen, reinforcing how subtle hormonal changes can alter the body’s response to endocannabinoids and cannabinoids.
"Eat, Sleep, Relax, Forget, Protect" is a powerful phrase first introduced by ECS researcher Vincenzo Di Marzo in 1998 and later expanded upon by Dr. Michelle Sexton in her 2023 book. Di Marzo originally proposed that endocannabinoids (ECBs) act as stress recovery factors, essential for survival. He identified the endocannabinoid system (ECS) as a critical network of receptors and molecules throughout the body that helps regulate key physiological processes such as mood, memory, appetite, pain, and sleep. This system works to maintain balance within the body by modulating the autonomic nervous system (McPartland et al, 2014).
The concept of "Eat, Sleep, Relax, Forget, Protect" underscores the vital role the ECS plays in promoting overall health and well-being. In her book, Dr. Sexton builds on Di Marzo's framework, using these five pillars as a guide to promoting holistic health. She highlights how the ECS supports adaptive processes crucial for survival, including memory, immune response, metabolism, mood regulation, and sleep. Together, these insights emphasize the ECS as a fundamental system for maintaining balance and resilience in the face of life’s challenges (Sexton,(2023).
In summary, the Endocannabinoid System (ECS) serves as the silent conductor of the body’s hormonal symphony, regulating everything from stress responses to the intricate balance of reproductive cycles and metabolic signals. Cannabinoids offer a natural and effective way to help restore these vital rhythms. With professional guidance from Holistic Caring & The Green Nurse, along with premium products from Bloom Hemp, individuals can take meaningful steps toward achieving balance and harmony—naturally and holistically.
With You on the Journey,
Nurses Sherri Mack BSN, RN & Elisabeth Mack MBA, BSN, RN
Content is brought to you by Holistic Caring & The Green Nurse and Bloom Hemp CBD.
Holistic Caring & The Green Nurse - Comprehensive cannabis education for patients and healthcare providers, including CEUs for nurses, along with expert coaching and consulting services.
Bloom Hemp CBD - Experience Doctor and Nurse-formulated Organic Hemp CBD, crafted with Ayurvedic inspiration and designed to target specific symptoms. Benefit from free access to a nurse hotline and personalized care plans, thoughtfully provided by expert cannabis nurses. Shop today, use promo code GREENURSE for 10% savings and free shipping.
References
Bloom Hemp. Focus Study: Bloom Hemp Advanced Focus Tincture. https://bloomhemp.com/focus-study-bloom/
CannaKeys.THC & CBD for hypothyroidism. https://cannakeys.com/thc-cbd-for-hypothyroidism/
Cristino L, Becker T, Di Marzo V. Endocannabinoids and energy homeostasis: an update. Biofactors. 2014 Jul-Aug;40(4):389-97. doi: 10.1002/biof.1168. Epub 2014 Apr 21. PMID: 24752980. https://pubmed.ncbi.nlm.nih.gov/24752980/
Di Marzo, V. (2008). The endocannabinoid system in obesity and type 2 diabetes. Diabetologia, 51(8), 1356–1367. https://doi.org/10.1007/s00125-008-1048-2
Hill, M. N., & Tasker, J. G. (2012). Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the HPA axis. Neuroscience, 204, 5–16. https://doi.org/10.1016/j.neuroscience.2011.12.030
Hillard CJ. Endocannabinoids and the Endocrine System in Health and Disease. Handb Exp Pharmacol. 2015;231:317-39. doi: 10.1007/978-3-319-20825-1_11. PMID: 26408166; PMCID: PMC6813821. https://pmc.ncbi.nlm.nih.gov/articles/PMC6813821/
Holistic Caring. The Endocannabinoid System (ECS) https://holisticcaring.com/ecs/
Lemoine, H. (2020). The endocannabinoid system: Effects of cannabis on female reproduction. Online Scientific Research. https://onlinescientificresearch.com/articles/the-endocannabinoid-system-effects-of-cannabis-on-female-reproduction.pdf
McPartland JM, Guy GW, Di Marzo V. (2014) Care and feeding of the endocannabinoid system: a systematic review of potential clinical interventions that upregulate the endocannabinoid system. https://pmc.ncbi.nlm.nih.gov/articles/PMC3951193/
Milanian, S., et al. (2025). A review of cellular and molecular interactions between endocannabinoids and male fertility: Balancing beneficial and detrimental effects. Life Sciences, 327, 124785. https://www.sciencedirect.com/science/article/abs/pii/S0024320525004138?via%3Dihub
Russo, E. B. (2016). Clinical endocannabinoid deficiency reconsidered: Current research supports the theory in migraine, fibromyalgia, irritable bowel, and other treatment-resistant syndromes. Cannabis and Cannabinoid Research, 1(1), 154–165. https://www.liebertpub.com/doi/10.1089/can.2016.0009
Sexton, M. (2023). Eat, Sleep, Relax, Protect, Forget: An Endocannabinoid (ECS) Guide to Systems Wholeness for Women. Wayfaring Woman Publishing. https://www.ecsdoctor.com/book
Silvestri, C., Paris, D., Martella, A., Melck, D., Guadagnino, I., & Di Marzo, V. (2015). Two non-psychoactive cannabinoids reduce intracellular lipid levels and inhibit hepatosteatosis. Journal of Hepatology, 62(6), 1382–1390. https://www.journal-of-hepatology.eu/article/S0168-8278(15)00003-3/abstract
Wargent, E. T., Zaibi, M. S., Silvestri, C., et al. (2013). The cannabinoid Δ⁹-THCV has anti-obesity activity and improves insulin sensitivity in two mouse models of obesity. Nutrition & Diabetes, 3(5), e68. https://www.nature.com/articles/nutd20139
Quarta, C., Mazza, R., Obici, S., Pasquali, R., & Pagotto, U. (2013). Energy balance regulation by endocannabinoids at central and peripheral levels. Trends in Molecular Medicine, 19(7), 371–379. https://doi.org/10.1016/j.molmed.2013.04.004
Elisabeth Mack, RN, BSN, MBA and Sherri Mack, BSN-RN are visionary leaders in cannabis and holistic nursing. Elisabeth, Founder & CEO of Holistic Caring and The Green Nurse, established her company in 2016 to bridge the gap between traditional healthcare and cannabis therapeutics. With a background in corporate healthcare and a passion for root-cause healing, she created the Holistic Caring CBD Health Coach Program, which trains and certifies nurses and health professionals to safely integrate cannabis into their practice.
Sherri brings 35+ years of nursing experience, including two decades in holistic care and over 10 years in plant medicine. She serves as Chief Nursing Officer at Holistic Caring & The Green Nurse, Vice President of Nursing at Bloom Hemp CBD, and host of The Green Nurse Podcast. Together, they educate and empower professionals through CE-accredited programs, community advocacy, and clinical guidance—redefining wellness through the endocannabinoid system and integrative care.